Endocrine Abstracts

Mild autonomous cortisol secretion (MACS) has been associated with cardiometabolic risk factors and cardiovascular disease in the 2000s and with increased mortality in the 2010s. Since the range of cortisol after dexamethasone suppression (cortisolDST) in MACS is wide, the associated risk may vary. To adequately decide treatment, the risk associated to the different levels of cortisolDST must be known. This year the ENSAT group published a study on cardio...

Background: Low levels of DHEAS, such as <1.04 µmol/l, have been used as a criterion for autonomous cortisol secretion (ACS) in patients with adrenal incidentalomas. Age- and gender-specific cut-off levels could theoretically improve DHEAS as a marker of HPA-axis suppression and as a criterion for ACS.Objective: We aimed to find cut-off levels of DHEAS that are best associated with HPA-axis suppression and determine whether they are correlated w...

Introduction: The specificity of cortisol after 1 mg dexamethasone (cortisolDST) ≥50 nmol/l as a criterion for mild autonomous cortisol secretion (MACS) is approximately 80% in patients with adrenal incidentalomas (AI). The aim was to study the associations of cortisolDSTto age, BMI, and renal function. We used machine learning models to uncover potential non-linear associations.Methods: We studied 1129 patients with AI examin...

Background: Autonomous cortisol secretion (ACS) in patients with adrenal incidentalomas (AI) has been associated with increased mortality in previous small studies. Our aim was to evaluate if ACS is a risk factor for mortality in a large population of patients with AI.Methods: Consecutive patients examined for adrenal adenomas, found as AI, without catecholamine or aldosterone hypersecretion between 2005 and 2015 were included and followed for up to 14 y...